Systematic CRISPR screens in primary CD4+ T cells unveil 25+ pro- and anti-HIV factors, revealing diverse antiviral mechanisms and targeting strategies. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New method, VIS-seq, analyzes 3,000 LMNA & PTEN variants, revealing complex, disease-specific effects on cell phenotypes through high-dimensional imaging. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Single-cell D&D-seq reveals precise DNA-protein interactions, unlocking insights into gene regulation by TFs. This tool transforms understanding of chromatin dynamics. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear and cytosolic proteomics of NSCs reveal abundant cytoskeletal proteins like MAP1B, which shuttle to the nucleus, linking microtubule dynamics to cellular fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A new model reveals how physical constraints shape the intricate topology of mammalian cortical connectomes, highlighting unique regional connectivity profiles. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study uncovers xenophagocytosis, where host macrophages eliminate xenogeneic donor cells in organ transplantation. Blocking this process increases interspecies chimerism! PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals FET proteins and PARylation aid DNA repair. Upon PARG inhibition, replication fork reversal occurs. Key in cancer therapy. Insights into genome stability! PMID:42380136, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74950-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP triggers membrane shearing via 3TM proteins in the CBASS antiviral system, revealing key mechanisms in prokaryotic immunity against phages. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits & veggies found garlic a strong deterrent of mating & egg-laying in Drosophila. Diallyl disulfide blocked both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover PRIME: a hybrid deep learning tool to pinpoint metal-binding sites in metalloproteins with unmatched accuracy. Revolutionizing studies with complex proteins! 🔬 PMID:42380105, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74657-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 2 co-circulating clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats; one clade binds human ACE2 efficiently—possible pandemic threat. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that the neuronal gene Arc is essential for tau release in EVs. rTg4510 model EVs from Arc KO mice show 50% less tau, impairing seeding potential. PMID:42372723, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Bora, CEP192, and Cenexin selectively regulate Plk1 processes: Bora aids mitotic entry; CEP192 in centrosome maturation; Cenexin in centriole disengagement. Science! PMID:42380115, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75033-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study shows specific gut metabolites worsen cognitive deficits and tau pathology in hTau.P301S mice. Antibiotics surprisingly make things worse! Neurodegenerative link? PMID:42380200, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74775-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replaying 100+ monoclonal germinal center reactions reveals how B cell competition drives antibody affinity evolution, reshaping immunoglobulin gene dynamics. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 470 angiosperms reveals 132 ancient WGD events show non-random clustering, highlighting polyploidy’s key role in evolution amid upheaval. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat stress increases susceptibility to metabolic dysfunction via elevated skin-derived KLK14, affecting hypothalamic LRRC7+ astrocytes in mice. Fascinating link! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, merging gene regulatory networks with RNA velocity analysis to identify 10+ potential regulators influencing cell fate transitions. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 12 cave lion genomes spanning 100k+ years show cave and modern lions were distinct lineages with separate histories and unique mutations! PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Furmonertinib 160 mg daily shows mPFS of 16.59 mo in 40 untreated EGFR-mutant NSCLC patients with CNS metastases. PMID:42379171, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00321-6?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG 🧪