Transposable elements shape our genome by associating with epigenomic marks across 4867 ChIP datasets, influencing regulatory roles in various cell types. PMID:42386716, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74920-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of human fertilized eggs fail to develop due to error-prone second mitotic divisions. Stochastic centriole overduplication leads to arrest, effectively reduced by PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts beyond the CANTOS trial's NNT limitations. #CancerResearch PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A GWAS on 382 Hispanic newborns revealed 6 significant loci for 24 neonatal blood traits, highlighting chromosome 2p11.2's CD8A. #Genetics PMID:42385717, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S000292972600234X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study of 12 cave lion genomes from over 100,000 years shows cave and modern lions are distinct lineages with unique genes and demographic histories, plus evidence of ancient gene flow. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA 🧪

#大学の生命科学を独学できるYouTube動画

黒田さん(静岡大在籍時)
「#分子生物学」
14 / 14

黒田裕樹の生物学講義〜分子生物学第14回
『#遺伝子解読 と #RNA干渉』
https://www.youtube.com/watch?...
49:47

#遺伝子 #解読 #RNA #干渉
#ゲノム #DNA
#生物 #大学生物 #生物学
#生命 #生命科学

Hippocampal theta sweeps show goal direction in navigation by evaluating potential future trajectories in under 121 cycles. Fascinating data! PMID:42386950, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02365-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights on SARS-CoV-2 relatives found in Thai horseshoe bats reveal 2 co-circulating clades; one binds human ACE2 tightly, raising pandemic concerns. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replayed 100+ GC reactions to uncover B cell competition dynamics; deep mutational scanning revealed key affinity shifts, illuminating antibody evolution. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Phase 3 trial: adjuvant pembrolizumab + belzutifan tested on patients with clear-cell renal-cell carcinoma. Aim: better survival, less recurrence. PMID:42384869, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2518245 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how Complex I's intricate structure enables >300 Å proton-coupled electron transfer. A carboxylate switch point in the E-channel proves essential. Dive in! PMID:42386739, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74767-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host metabolism using B. fragilis toxin, driving oxidative growth in the inflamed gut. This interaction reveals a new strategy for anaerobic pathogens in nutrient-rich environments. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #RNA 🧪

Study reveals hippocampal neurons show shared semantic responses in bilinguals, highlighting "cross-language neurons" for concepts like "tierra" and "earth." Fascinating! PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

D-SPIN revolutionizes gene regulatory networks by integrating single-cell mRNA-seq data, unveiling 3 key principles of cellular response to 5 disturbances and enhancing 7 homeostasis mechanisms. PMID:42127893, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00463-0 #Medsky #RNA 🧪

p53 is crucial for safe and efficient reprogramming of human somatic cells to pluripotency, balancing genome stability while opposing oncogenic risks. #p53 PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hot off the press from the RTI: Population genetics, trait mapping and fungal pathogen surveillance using untargeted sequencing in timber rattlesnakes (Crotalus horridus)
buff.ly/mbA1ICW #RNA #RNATherapeutics

Bluesky
RNA therapeutics are advancing fast. The outsourcing ecosystem has to keep up.
Chief Editor Louis Garguilo looks at how CDMOs, academia, automation and new service models could reshape RNA development and manufacturing.
www.outsourcedpharma.com/doc/cdmos-co...
#RNA #CDMO #Biopharma

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, identifying 100+ potential regulators influencing cell fate changes. Exciting times ahead! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights from single-cell and multi-omics reveal 10 unique senotypes in human tissues linked to aging and disease, paving the way for 5 targeted senotherapeutic strategies. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG 🧪

Study finds TCF1 alone doesn't define stem-like T cells in chronic disease; LEF1 and niche factors also crucial for T cell stemness in autoimmunity & chronic infection. #TcellResearch PMID:42385703, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00709-9 #Medsky #Pharmsky #RNA 🧪