Nuclear metabolism links to gene regulation: ACO2 & IDH2 localize in the nucleus, catalyzing α-ketoglutarate reductive carboxylation for histone acetylation & gene activation. PMID:42386731, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74786-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The Pharmacology Learning Objectives support faculty in developing, delivering, and assessing pharmacology content, with the flexibility to adapt them to the goals, structure, and instructional time of individual curricula. Download your copy: https://ow.ly/P6w850ZUEHP
#pharmsky 🧪

The Pharmacology Learning Objectives support faculty in developing, delivering, and assessing pharmacology content, with the flexibility to adapt them to the goals, structure, and instructional time of individual curricula. Download your copy: https://ow.ly/P6w850ZUEHP
#pharmsky 🧪

Synthetic mRNA with N⁴-Acetylcytidine boosts translation yield, fidelity, and stability. Outperforms standard m¹Ψ in cancer and infection treatments. PMID:42386968, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10729-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin, a cancer treatment, triggers DNA damage in neurons via NER, leading to cell death rather than protection, revealing a critical vulnerability in post-mitotic tissues. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG 🧪

New insights: Coccidioides arthroconidia activate TLR2 and induce NLRP3-pyrin inflammasomes in macrophages. Ferroptotic signaling aids fungal killing. Stay informed! PMID:42386736, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75022-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements shape our genome by associating with epigenomic marks across 4867 ChIP datasets, influencing regulatory roles in various cell types. PMID:42386716, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74920-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of human fertilized eggs fail to develop due to error-prone second mitotic divisions. Stochastic centriole overduplication leads to arrest, effectively reduced by PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts beyond the CANTOS trial's NNT limitations. #CancerResearch PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A GWAS on 382 Hispanic newborns revealed 6 significant loci for 24 neonatal blood traits, highlighting chromosome 2p11.2's CD8A. #Genetics PMID:42385717, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S000292972600234X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study of 12 cave lion genomes from over 100,000 years shows cave and modern lions are distinct lineages with unique genes and demographic histories, plus evidence of ancient gene flow. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA 🧪

Hippocampal theta sweeps show goal direction in navigation by evaluating potential future trajectories in under 121 cycles. Fascinating data! PMID:42386950, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02365-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights on SARS-CoV-2 relatives found in Thai horseshoe bats reveal 2 co-circulating clades; one binds human ACE2 tightly, raising pandemic concerns. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replayed 100+ GC reactions to uncover B cell competition dynamics; deep mutational scanning revealed key affinity shifts, illuminating antibody evolution. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway, key for innate immunity, detects dsDNA, influencing 3 key areas: antiviral defense, tissue homeostasis, and antitumor immunity, yet linked to 6 inflammatory disorders. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky 🧪

Phase 3 trial: adjuvant pembrolizumab + belzutifan tested on patients with clear-cell renal-cell carcinoma. Aim: better survival, less recurrence. PMID:42384869, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2518245 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how Complex I's intricate structure enables >300 Å proton-coupled electron transfer. A carboxylate switch point in the E-channel proves essential. Dive in! PMID:42386739, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74767-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals hippocampal neurons show shared semantic responses in bilinguals, highlighting "cross-language neurons" for concepts like "tierra" and "earth." Fascinating! PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

In JPET's editor's choice, data provides multiple potential pharmacological targets to prevent prostate cancer metastasis, and circDOPEY2 can be used as a biomarker to track the increased likelihood of prostate cancer metastasis. Read the research: https://ow.ly/WTVf50ZUC55
#pharmsky 🧪

p53 is crucial for safe and efficient reprogramming of human somatic cells to pluripotency, balancing genome stability while opposing oncogenic risks. #p53 PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪