New trimodal platform enables simultaneous in vivo Ca²⁺ imaging, neuron morphology reconstruction, and in situ transcriptomic profiling, advancing neuron function insights. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@ajhgnews.bsky.social is a home for discoveries, statistical methods, & ideas that move the field forward. Hear from Editorial Board member Loic Yengo, PhD, on why AJHG is a trusted destination for readers & researchers alike. Learn more & submit your work: https://bit.ly/46Qu4G #ASHG

Alzheimer's disease shows over 1,000× enrichment of somatic mutations in cancer driver genes, especially in those linked to clonal hematopoiesis, driving microglial expansion! PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A novel in vivo screening platform was created using 84 CRISPR-Cas9 knockout mouse lines to validate host factors in influenza A research, bridging vital gaps in virology! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A recent study on recurrent GBM highlighted that CAR T cell therapy showed early promise but nearly 50% relapse rates indicate a crucial role for immune response in outcomes. PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur splits pathways for growth: it fuels GSH and Fe-S clusters, enhancing CD8⁺ T cell proliferation and anti-tumor immunity—metabolic choice matters! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 safeguards the reprogramming of human somatic cells to pluripotency by ensuring genome stability, balancing risk through regulation of the Yamanaka factors. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts after CANTOS showed IL-1β inhibition benefits. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionary seqFISH+ spatial transcriptomics mapped 2,653 genes in 867,062 mouse testis cells, revealing Sertoli cells' unique cyclic transcription aligned with sperm development! PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG 🧪

New research reveals TMEM154/Galvanin as a key receptor enabling cells to detect electric fields, directing migration towards the cathode, pivotal for cell behavior. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium, driven by IL-6 during E. coli infection, boosts nociceptive pathways and chronic pain via SLC7A11-glutamate. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study maps ~89,000 genetic interactions in HAP1 cells from ~4M CRISPR perturbations, revealing hierarchical modules that clarify gene co-essentiality. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting insights on VPS13A, a bridge-like lipid transfer protein, reveal its complex with scramblase XK, illuminating lipid transfer mechanisms at organelle contact sites! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Primate organogenetic embryoids created from cynomolgus totipotent blastomere-like stem cells (cTBLCs) reveal key totipotent features, advancing embryonic development models. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A unique type of parvalbumin-expressing inhibitory neurons in the basal forebrain enhances sustained attention, revealing a new neural circuit beyond cholinergic neurons. #Attention PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG 🧪

Systematic CRISPR screens in primary CD4+ T cells unveil 25+ pro- and anti-HIV factors, revealing diverse antiviral mechanisms and targeting strategies. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New method, VIS-seq, analyzes 3,000 LMNA & PTEN variants, revealing complex, disease-specific effects on cell phenotypes through high-dimensional imaging. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Single-cell D&D-seq reveals precise DNA-protein interactions, unlocking insights into gene regulation by TFs. This tool transforms understanding of chromatin dynamics. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear and cytosolic proteomics of NSCs reveal abundant cytoskeletal proteins like MAP1B, which shuttle to the nucleus, linking microtubule dynamics to cellular fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A new model reveals how physical constraints shape the intricate topology of mammalian cortical connectomes, highlighting unique regional connectivity profiles. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪