Alphavirus M1, via NSP2, disrupts super-enhancer oncogenic transcription in osteosarcoma. Surprisingly, this isn’t just about ER stress or RPB1 involvement. PMID:42386745, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75013-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how plants respond to touch! A MAPKKK3/4/5-MKK4/5-MPK3/6 cascade is activated in 60s, inducing 800 genes—key for early mechanostimulation response. 🌿 PMID:42386747, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74994-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New tech D&D-seq maps DNA-protein interactions in single cells, revealing insights on TF binding and chromatin states, bridging gaps in gene expression control! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery of GPNMB CAR T cells unlocks multi-cancer therapy potential, refining targets via single-cell RNA sequencing from 10K+ datasets. Exciting advancements ahead! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Discover how quasisymmetric one-component protein nanocages can revolutionize biologics delivery with virus-like assemblies of 100s-1000s of subunits! 🚀 PMID:42162430, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10554-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New Nature paper reveals replication stress causes chromatin loops to form, enclosing stalled forks at CTCF motifs, aiding genome integrity; join the convo! PMID:42386978, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

African proteomic study unlocks Alzheimer's insights. Nigerian and Tanzanian cohorts reveal plasma profiles linked to amyloid pathology; breakthrough in ADRD research! PMID:42386726, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74971-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Boost T cell therapy! Targeting CD2/CD7 increases nanoparticle delivery to CD4+ T cells—significantly higher uptake versus CD3/CD28. Transforming treatments! PMID:42386746, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74981-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

LEAPER 3.0 enhances RNA editing via engineered ADAR-recruiting RNAs. It leverages AlphaFold 3 for precision, expanding efficient editing strategies. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering a Buchnera protein key for host cell colonization boosts understanding of endosymbiont entry and immune suppression in insects! PMID:42386962, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10711-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering the Plasmodium moving junction structure unveils a sailboat-shaped 1:1:1:1 assembly of PfAMA1 with PfRON2, PfRON4, and PfRON5, crucial for malaria invasion! PMID:42379167, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00699-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat stress increases susceptibility to metabolic dysfunction in mice on an obesogenic diet. Elevated skin-derived KLK14 affects hypothalamic LRRC7+ astrocytes. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel model reveals mammalian cortical connectomes exhibit ⌀ topology influenced by physical constraints, focusing connectivity into distinct regions. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new method, variant in situ sequencing (VIS-seq), measures effects of ~3,000 LMNA & PTEN variants, revealing complex, high-dimensional phenotypes in cell architecture. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear metabolism links to gene regulation: ACO2 & IDH2 localize in the nucleus, catalyzing α-ketoglutarate reductive carboxylation for histone acetylation & gene activation. PMID:42386731, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74786-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The Pharmacology Learning Objectives support faculty in developing, delivering, and assessing pharmacology content, with the flexibility to adapt them to the goals, structure, and instructional time of individual curricula. Download your copy: https://ow.ly/P6w850ZUEHP
#pharmsky 🧪

The Pharmacology Learning Objectives support faculty in developing, delivering, and assessing pharmacology content, with the flexibility to adapt them to the goals, structure, and instructional time of individual curricula. Download your copy: https://ow.ly/P6w850ZUEHP
#pharmsky 🧪

Synthetic mRNA with N⁴-Acetylcytidine boosts translation yield, fidelity, and stability. Outperforms standard m¹Ψ in cancer and infection treatments. PMID:42386968, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10729-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin, a cancer treatment, triggers DNA damage in neurons via NER, leading to cell death rather than protection, revealing a critical vulnerability in post-mitotic tissues. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG 🧪

New insights: Coccidioides arthroconidia activate TLR2 and induce NLRP3-pyrin inflammasomes in macrophages. Ferroptotic signaling aids fungal killing. Stay informed! PMID:42386736, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75022-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪