A recent study on recurrent GBM highlighted that CAR T cell therapy showed early promise but nearly 50% relapse rates indicate a crucial role for immune response in outcomes. PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur splits pathways for growth: it fuels GSH and Fe-S clusters, enhancing CD8⁺ T cell proliferation and anti-tumor immunity—metabolic choice matters! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 safeguards the reprogramming of human somatic cells to pluripotency by ensuring genome stability, balancing risk through regulation of the Yamanaka factors. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts after CANTOS showed IL-1β inhibition benefits. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals TMEM154/Galvanin as a key receptor enabling cells to detect electric fields, directing migration towards the cathode, pivotal for cell behavior. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium, driven by IL-6 during E. coli infection, boosts nociceptive pathways and chronic pain via SLC7A11-glutamate. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study maps ~89,000 genetic interactions in HAP1 cells from ~4M CRISPR perturbations, revealing hierarchical modules that clarify gene co-essentiality. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting insights on VPS13A, a bridge-like lipid transfer protein, reveal its complex with scramblase XK, illuminating lipid transfer mechanisms at organelle contact sites! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Primate organogenetic embryoids created from cynomolgus totipotent blastomere-like stem cells (cTBLCs) reveal key totipotent features, advancing embryonic development models. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic CRISPR screens in primary CD4+ T cells unveil 25+ pro- and anti-HIV factors, revealing diverse antiviral mechanisms and targeting strategies. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New method, VIS-seq, analyzes 3,000 LMNA & PTEN variants, revealing complex, disease-specific effects on cell phenotypes through high-dimensional imaging. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Single-cell D&D-seq reveals precise DNA-protein interactions, unlocking insights into gene regulation by TFs. This tool transforms understanding of chromatin dynamics. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new model reveals how physical constraints shape the intricate topology of mammalian cortical connectomes, highlighting unique regional connectivity profiles. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study uncovers xenophagocytosis, where host macrophages eliminate xenogeneic donor cells in organ transplantation. Blocking this process increases interspecies chimerism! PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals FET proteins and PARylation aid DNA repair. Upon PARG inhibition, replication fork reversal occurs. Key in cancer therapy. Insights into genome stability! PMID:42380136, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74950-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP triggers membrane shearing via 3TM proteins in the CBASS antiviral system, revealing key mechanisms in prokaryotic immunity against phages. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits & veggies found garlic a strong deterrent of mating & egg-laying in Drosophila. Diallyl disulfide blocked both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover PRIME: a hybrid deep learning tool to pinpoint metal-binding sites in metalloproteins with unmatched accuracy. Revolutionizing studies with complex proteins! 🔬 PMID:42380105, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74657-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 2 co-circulating clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats; one clade binds human ACE2 efficiently—possible pandemic threat. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that the neuronal gene Arc is essential for tau release in EVs. rTg4510 model EVs from Arc KO mice show 50% less tau, impairing seeding potential. PMID:42372723, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪