A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts beyond the CANTOS trial's NNT limitations. #CancerResearch PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A GWAS on 382 Hispanic newborns revealed 6 significant loci for 24 neonatal blood traits, highlighting chromosome 2p11.2's CD8A. #Genetics PMID:42385717, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S000292972600234X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hippocampal theta sweeps show goal direction in navigation by evaluating potential future trajectories in under 121 cycles. Fascinating data! PMID:42386950, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02365-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights on SARS-CoV-2 relatives found in Thai horseshoe bats reveal 2 co-circulating clades; one binds human ACE2 tightly, raising pandemic concerns. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replayed 100+ GC reactions to uncover B cell competition dynamics; deep mutational scanning revealed key affinity shifts, illuminating antibody evolution. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Phase 3 trial: adjuvant pembrolizumab + belzutifan tested on patients with clear-cell renal-cell carcinoma. Aim: better survival, less recurrence. PMID:42384869, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2518245 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how Complex I's intricate structure enables >300 Å proton-coupled electron transfer. A carboxylate switch point in the E-channel proves essential. Dive in! PMID:42386739, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74767-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals hippocampal neurons show shared semantic responses in bilinguals, highlighting "cross-language neurons" for concepts like "tierra" and "earth." Fascinating! PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Our Know Before You Go webinar is TOMORROW. Join us at 12 pm U.S. ET for practical insider tips on how to make the most of your time in Montréal. Plus, bring your questions for a live Q&A. Register now: https://bit.ly/3VdApJ3 #ASHG26 #ASHG #HumanGenetics

p53 is crucial for safe and efficient reprogramming of human somatic cells to pluripotency, balancing genome stability while opposing oncogenic risks. #p53 PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, identifying 100+ potential regulators influencing cell fate changes. Exciting times ahead! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights from single-cell and multi-omics reveal 10 unique senotypes in human tissues linked to aging and disease, paving the way for 5 targeted senotherapeutic strategies. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG 🧪

Shining light on congenital myasthenia: correcting acetylcholine receptor mutations may improve muscle function and transform lives. Are breakthroughs near? PMID:42386970, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10706-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals Arc is essential for tau release via extracellular vesicles; rTg4510/Arc KO mice show reduced tau and seeding potential—key insights into neurodegeneration! PMID:42372723, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how treatment thresholds in psychiatry are reshaped by clinimetric advances; key for optimized patient care in 2023. PMID:42384391, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1759 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

DNA hypomethylation in tomatoes aids SlSPL-CNR to bind and repress SlAAT1, altering f… PMID:42386734, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-75181-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: 27 volunteers challenged with A/H3N2, 22 infected, 18 symptomatic. Rapid innate immune response linked to symptoms. PMID:42387215, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04483-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore the role of NUDT5 in 6-TG response; inhibition matters more than loss, boosti… PMID:42380098, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74489-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how the IDP ALMS1 influences centriole biogenesis! It catalyzes cartwheel formation by organizing CEP152 without becoming part of the structure itself. PMID:42380124, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74821-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New trimodal platform enables simultaneous in vivo Ca²⁺ imaging, neuron morphology reconstruction, and in situ transcriptomic profiling, advancing neuron function insights. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪